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dc.contributor.authorHansen, Bjørn Henrik
dc.contributor.authorFarkas, Julia
dc.contributor.authorPiarulli, Stefania
dc.contributor.authorVicario, Silvia
dc.contributor.authorKvæstad, Bjarne
dc.contributor.authorWilliamson, David Roddan
dc.contributor.authorSørensen, Lisbet
dc.contributor.authorDavies, Emlyn John
dc.contributor.authorNordtug, Trond
dc.date.accessioned2022-09-19T09:55:01Z
dc.date.available2022-09-19T09:55:01Z
dc.date.created2021-10-20T22:20:03Z
dc.date.issued2021
dc.identifier.citationToxicology reports. 2021, 8 1754-1761.en_US
dc.identifier.issn2214-7500
dc.identifier.urihttps://hdl.handle.net/11250/3018829
dc.description.abstract3,4-dichloroaniline (3,4-DCA) is one of the most widely produced anilines world-wide, used in plastic packaging, fabrics, pharmaceuticals, pesticides, dyes and paints as well as being a degradation product of several pesticides. 3,4-DCA has been detected in freshwater, brackish and marine environments. Although freshwater toxicity thresholds exist, very little toxicological information is available on marine and cold-water species. In this study, we exposed Atlantic cod (Gadus morhua) embryos (3–7 days post fertilization) to 3,4-DCA concentrations ranging from 8−747 μg/L for 4 days followed by a recovery period in clean sea water until 14 days post fertilization (dpf). The cod embryos were significantly more sensitive to acute 3,4-DCA exposure compared to other species tested and reported in the literature. At the highest concentration (747 μg/L), no embryos survived until hatch, and even at the lowest concentration (8 μg/L), a small, but significant increase in mortality was observed at 14 dpf. Delayed and concentration-dependent effects on surviving yolk-sac larvae, manifested as cardiac, developmental and morphometric alterations, more than a week after exposure suggest potential long-term effects of transient embryonic exposure to low concentrations of 3,4-DCA.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectCardiotoxicityen_US
dc.subjectEmbryotoxicityen_US
dc.subjectComparative ecotoxicityen_US
dc.subjectEmerging pollutantsen_US
dc.subject3,4-DCAen_US
dc.titleAtlantic cod (Gadus morhua) embryos are highly sensitive to short-term 3,4-dichloroaniline exposureen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Authors. Published by Elsevier B.Ven_US
dc.source.pagenumber1754-1761en_US
dc.source.volume8en_US
dc.source.journalToxicology reportsen_US
dc.identifier.doi10.1016/j.toxrep.2021.10.006
dc.identifier.cristin1947447
dc.relation.projectNorges forskningsråd: 280511en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal