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dc.contributor.authorLee, Sung Hyun
dc.contributor.authorMizushima, Kota
dc.contributor.authorYonai, Shunsuke
dc.contributor.authorMatsumoto, Shinnosuke
dc.contributor.authorMizuno, Hideyuki
dc.contributor.authorNakaji, Taku
dc.contributor.authorKohno, Ryosuke
dc.contributor.authorIwata, Yoshiyuki
dc.contributor.authorShirai, Toshiyuki
dc.contributor.authorPan, Vladimir
dc.contributor.authorKok, Angela
dc.contributor.authorPovoli, Marco
dc.contributor.authorTran, Linh T.
dc.contributor.authorRosenfeld, Anatoly B.
dc.contributor.authorSuzuki, Masao
dc.contributor.authorInaniwa, Taku
dc.identifier.citationApplied Sciences. 2022, 12 (12), 6148.en_US
dc.description.abstractExperimental microdosimetry along with the microdosimetric kinetic (MK) model can be utilized to predict the biological effects of ions. To predict the relative biological effectiveness (RBE) of ions and the survival fraction (SF) of human salivary gland tumour (HSGc-C5) cells, microdosimetric quantities measured by a silicon-on-insulator (SOI) MicroPlus-mushroom microdosimeter along the spread-out Bragg peak (SOBP) delivered by pencil beam scanning of 4He, 12C, 16O, and 20Ne ions were used. The MK model parameters of HSGc-C5 cells were obtained from the best fit of the calculated SF for the different linear energy transfer (LET) of these ions and the formerly reported in vitro SF for the same LET and ions used for calculations. For a cube-shaped target of 10 × 10 × 6 cm3, treatment plans for 4He, 12C, 16O, and 20Ne ions were produced with proprietary treatment planning software (TPS) aiming for 10% SF of HSGc-C5 cells over the target volume and were delivered to a polymethyl methacrylate (PMMA) phantom. Afterwards, the saturation-corrected dose-mean lineal energy derived based on the measured microdosimetry spectra, along with the physical dose at various depths in PMMA phantoms, was used for the estimation of the SF, RBE, and RBE-weighted dose using the MK model. The predicted SF, RBE, and the RBE-weighted dose agreed with what was planned by the TPS within 3% at most depths for these ions.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titlePredicting the Biological Effects of Human Salivary Gland Tumour Cells for Scanned 4He-, 12C-, 16O-, and 20Ne-Ion Beams Using an SOI Microdosimeteren_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2022 by the authors.en_US
dc.source.journalApplied Sciencesen_US

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