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dc.contributor.authorHou, Jie
dc.contributor.authorNess, Siri Schøne
dc.contributor.authorTschudi, Jon
dc.contributor.authorO'Farrell, Marion
dc.contributor.authorVeddegjerde, Rune
dc.contributor.authorMartinsen, Ørjan Grøttem
dc.contributor.authorTønnessen, Tor Inge
dc.contributor.authorStrand-Amundsen, Runar James
dc.date.accessioned2023-02-21T15:26:12Z
dc.date.available2023-02-21T15:26:12Z
dc.date.created2022-12-26T13:15:19Z
dc.date.issued2022
dc.identifier.citationSensors. 2022, 22 (23), 9111.en_US
dc.identifier.issn1424-8220
dc.identifier.urihttps://hdl.handle.net/11250/3052865
dc.description.abstractA porcine model was used to investigate the feasibility of using VIS-NIR spectroscopy to differentiate between degrees of ischemia–reperfusion injury in the small intestine. Ten pigs were used in this study and four segments were created in the small intestine of each pig: (1) control, (2) full arterial and venous mesenteric occlusion for 8 h, (3) arterial and venous mesenteric occlusion for 2 h followed by reperfusion for 6 h, and (4) arterial and venous mesenteric occlusion for 4 h followed by reperfusion for 4 h. Two models were built using partial least square discriminant analysis. The first model was able to differentiate between the control, ischemic, and reperfused intestinal segments with an average accuracy of 99.2% with 10-fold cross-validation, and the second model was able to discriminate between the viable versus non-viable intestinal segments with an average accuracy of 96.0% using 10-fold cross-validation. Moreover, histopathology was used to investigate the borderline between viable and non-viable intestinal segments. The VIS-NIR spectroscopy method together with a PLS-DA model showed promising results and appears to be well-suited as a potentially real-time intraoperative method for assessing intestinal ischemia–reperfusion injury, due to its easy-to-use and non-invasive nature.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleAssessment of Intestinal Ischemia–Reperfusion Injury Using Diffuse Reflectance VIS-NIR Spectroscopy and Histologyen_US
dc.title.alternativeAssessment of Intestinal Ischemia–Reperfusion Injury Using Diffuse Reflectance VIS-NIR Spectroscopy and Histologyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2022 by the authorsen_US
dc.source.pagenumber16en_US
dc.source.volume22en_US
dc.source.journalSensorsen_US
dc.source.issue23en_US
dc.identifier.doi10.3390/s22239111
dc.identifier.cristin2097404
dc.source.articlenumber9111en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal