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dc.contributor.authorLaux, Peter
dc.contributor.authorRiebeling, Christian
dc.contributor.authorBooth, Andy
dc.contributor.authorBrain, Joseph
dc.contributor.authorBrunner, Josephine
dc.contributor.authorCerrillo, Cristina
dc.contributor.authorCreutzenberg, Otto
dc.contributor.authorEstrela-Lopis, Irina
dc.contributor.authorGebel, Thomas
dc.contributor.authorJohanson, Gunnar
dc.contributor.authorJungnickel, Harald
dc.contributor.authorKock, Heiko
dc.contributor.authorTentschert, Jutta
dc.contributor.authorTlili, Ahmed
dc.contributor.authorSchäffer, Andreas
dc.contributor.authorSips, Adriënne
dc.contributor.authorYokel, Robert A.
dc.contributor.authorLuch, Andreas
dc.date.accessioned2017-11-12T12:35:29Z
dc.date.available2017-11-12T12:35:29Z
dc.date.created2017-03-09T21:34:13Z
dc.date.issued2017-03-22
dc.identifier.citationNanoImpact. 2017, 6 69-80.nb_NO
dc.identifier.issn2452-0748
dc.identifier.urihttp://hdl.handle.net/11250/2465640
dc.description.abstractNanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined future categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity of NMs. It is unclear which criteria to apply to characterize a NM as biopersistent. Detection and quantification of NMs, especially determination of their state, i.e., dissolution, aggregation,and agglomeration within biological matrices and other environments are still challenging tasks; moreover mechanisms of nanoparticle (NP) translocation and persistence remain critical gaps. This review summarizes the current understanding of NM biokinetics focusing on determinants of biopersistence. Thorough particle characterization in different exposure scenarios and biological matrices requires use of suitable analytical methods and is a prerequisite to understand biopersistence and for the development of appropriate dosimetry. Analytical tools that potentially can facilitate elucidation of key NM characteristics, such as ion beam microscopy (IBM) and time-of-flight secondary ion mass spectrometry (ToFSIMS), are discussed in relation to their potential to advance the understanding of biopersistent NM kinetics. We conclude that a major requirement for future nanosafety research is the development and application of analytical tools to characterize NPs in different exposure scenarios and biological matrices.nb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse-Ikkekommersiell-DelPåSammeVilkår 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/deed.no*
dc.subjectBiokineticsnb_NO
dc.subjectDosimetrynb_NO
dc.subjectExtrapulmonary organsnb_NO
dc.subjectGranular biopersistent particle without known significant specific toxicity (GBP)nb_NO
dc.subjectInhalationnb_NO
dc.titleBiokinetics of Nanomaterials: The Role of Biopersistencenb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holder© 2017 The Authors. Published by Elsevier B.V.nb_NO
dc.source.pagenumber69-80nb_NO
dc.source.volume6nb_NO
dc.source.journalNanoImpactnb_NO
dc.identifier.doi10.1016/j.impact.2017.03.003
dc.identifier.cristin1457158
dc.relation.projectEU/310584nb_NO
dc.relation.projectNorges forskningsråd: 239199nb_NO
cristin.unitcode7566,6,0,0
cristin.unitnameMiljøteknologi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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