Browsing SINTEF Digital by Author "Hansen, Rune"
Now showing items 1-9 of 9
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Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy
Suica, Viorel I.; Uyy, Elena; Ivan, Luminita; Boteanu, Raluca M.; Cerveanu-Hogas, Aurel; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)Increased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of ... -
Formulation and characterisation of drug-loaded antibubbles for image-guided and ultrasound-triggered drug delivery
Kotopoulis, Spiros; Lam, Christina; Haugse, Ragnhild; Snipstad, Sofie; Murvold, Elsa Thodesen; Jouleh, Tæraneh; Berg, Sigrid; Hansen, Rune; Popa, Mihaela-Lucia; Mccormack, Emmet Matin; Gilja, Odd Helge; Poortinga, Albert (Peer reviewed; Journal article, 2022)The aim of this study was to develop high load-capacity antibubbles that can be visualized using diagnostic ultrasound and the encapsulated drug can be released and delivered using clinically translatable ultrasound. The ... -
Hepatic Alarmins and Mitochondrial Dysfunction under Residual Hyperlipidemic Stress Lead to Irreversible NAFLD
Ivan, Luminita; Uyy, Elena; Suica, Viorel; Boteanu, Raluca; Cerveanu-Hogas, Aurel; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)Background and Aims: Nonalcoholic fatty liver disease (NAFLD) includes a range of progressive disorders generated by excess lipid accumulation in the liver leading to hepatic steatosis and eventually fibrosis. We aimed to ... -
A multi-pulse ultrasound technique for imaging of thick-shelled microbubbles demonstrated in vitro and in vivo
Berg, Sigrid; Eggen, Siv; Caidahl, Kenneth; Dähne, Lars; Hansen, Rune (Peer reviewed; Journal article, 2022)Contrast enhanced ultrasound is a powerful diagnostic tool and ultrasound contrast media are based on microbubbles (MBs). The use of MBs in drug delivery applications and molecular imaging is a relatively new field of ... -
Regulated cell death joins in atherosclerotic plaque silent progression
Uyy, Elena; Suica, Viorel I.; Boteanu, Raluca M.; Cerveanu-Hogas, Aurel; Ivan, Luminita; Hansen, Rune; Antohe, Felicia (Peer reviewed; Journal article, 2022)Non-apoptotic regulated cell death (ferroptosis and necroptosis) leads to the release of damage-associated molecular patterns (DAMPs), which initiate and perpetuate a non-infectious inflammatory response. We hypothesize ... -
Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel
Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ... -
The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy
Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ... -
Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation
van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ... -
Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model
Baghirov, Habib; Snipstad, Sofie; Sulheim, Einar; Berg, Sigrid; Hansen, Rune; Thorsen, Frits; Mørch, Ýrr Asbjørg; Davies, Catharina de Lange; Åslund, Andreas (Journal article; Peer reviewed, 2018)The treatment of brain diseases is hindered by the blood-brain barrier (BBB) preventing most drugs from entering the brain. Focused ultrasound (FUS) with microbubbles can open the BBB safely and reversibly. Systemic drug ...