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dc.contributor.authorCant, David J H
dc.contributor.authorPei, Yiwen
dc.contributor.authorShchukarev, Andrey
dc.contributor.authorRamstedt, Madeleine
dc.contributor.authorMarques, Sara S.
dc.contributor.authorSegundo, Marcela A.
dc.contributor.authorParot, Jérémie
dc.contributor.authorMolska, Alicja Anna
dc.contributor.authorBorgos, Sven Even F.
dc.contributor.authorShard, Alexander G.
dc.contributor.authorMinelli, Caterina
dc.date.accessioned2024-04-22T07:14:22Z
dc.date.available2024-04-22T07:14:22Z
dc.date.created2023-11-08T10:42:22Z
dc.date.issued2023
dc.identifier.citationJournal of Physical Chemistry A. 2023, 127 (39), 8220-8227.en_US
dc.identifier.issn1089-5639
dc.identifier.urihttps://hdl.handle.net/11250/3127491
dc.description.abstractNanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative measurement of the surface chemistry and composition of such systems in a hydrated environment has thus far not been demonstrated, yet such measurements are of great importance for the development of nanomedicine systems. Here we demonstrate the first use of cryo-XPS for the measurement of two PEG-functionalized nanomedicines: a polymeric drug delivery system and a lipid nanoparticle mRNA carrier. The observed differences between cryo-XPS and standard XPS measurements indicate the potential of cryo-XPS for providing quantitative measurements of such nanoparticle systems in hydrated conditions.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleCryo-XPS for Surface Characterization of Nanomedicinesen_US
dc.title.alternativeCryo-XPS for Surface Characterization of Nanomedicinesen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.rights.holderAuthor Accepted Manuscript (AAM) shared under a CC-BY license.en_US
dc.source.pagenumber8220-8227en_US
dc.source.volume127en_US
dc.source.journalJournal of Physical Chemistry Aen_US
dc.source.issue39en_US
dc.identifier.doi10.1021/acs.jpca.3c03879
dc.identifier.cristin2193749
dc.relation.projectEC/H2020/825828en_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal