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dc.contributor.authorSaranya, Muthusamy
dc.contributor.authorda Silva, Aldeliane M.
dc.contributor.authorKarjalainen, Hanna
dc.contributor.authorKlinkenberg, Geir
dc.contributor.authorSchmid, Ruth Baumberger
dc.contributor.authorMcDonagh, Birgitte Hjelmeland
dc.contributor.authorMolesworth, Peter Patrick
dc.contributor.authorSigfúsdóttir, Margrét S.
dc.contributor.authorWågbø, Ane Marit
dc.contributor.authorSantos, Susana. G.
dc.contributor.authorCouto, Cristiana
dc.contributor.authorKarjalainen, Ville-Pauli
dc.contributor.authorGupta, Shuvashis Das
dc.contributor.authorJärvinen, Topias
dc.contributor.authorde Roy, Luisa
dc.contributor.authorSeitz, Andreas. M.
dc.contributor.authorFinnilä, Mikko
dc.contributor.authorSaarakkala, Simo
dc.contributor.authorHaaparanta, Anne Marie
dc.contributor.authorJanssen, Lauriane
dc.contributor.authorLorite, Gabriela S.
dc.identifier.citationAdvanced Healthcare Materials. 2023, 12 (30): 2301787.en_US
dc.description.abstractThe demand for engineered scaffolds capable of delivering multiple cues to cells continues to grow as the interplay between cell fate with microenvironmental and external cues is revealed. Emphasis has been given to develop stimuli-responsive scaffolds. These scaffolds are designed to sense an external stimulus triggering a specific response (e.g., change in the microenvironment, release therapeutics, etc.) and then initiate/modulate a desired biofunction. Here, magnetic-responsive carboxylated multi-walled carbon nanotubes (cMWCNTs) are integrated into 3D collagen/polylactic acid (PLA) scaffold via a reproducible filtration-based method. The integrity and biomechanical performance of the collagen/PLA scaffolds are preserved after cMWCNT integration. In vitro safety assessment of cMWCNT/collagen/PLA scaffolds shows neither cytotoxicity effects nor macrophage pro-inflammatory response, supporting further in vitro studies. The cMWCNT/collagen/PLA scaffolds enhance chondrocytes metabolic activity while maintaining high cell viability and extracellular matrix (i.e., type II collagen and aggrecan) production. Comprehensive in vitro study applying static and pulsed magnetic field on seeded scaffolds shows no specific cell response in dependence with the applied field. This result is independent of the presence or absence of cMWCNT into the collagen/PLA scaffolds. Taken together, these findings provide additional evidence of the benefits to exploit the CNTs outstanding properties in the design of stimuli-responsive scaffolds.en_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleMagnetic-Responsive Carbon Nanotubes Composite Scaffolds for Chondrogenic Tissue Engineeringen_US
dc.title.alternativeMagnetic-Responsive Carbon Nanotubes Composite Scaffolds for Chondrogenic Tissue Engineeringen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.rights.holder© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.en_US
dc.source.journalAdvanced Healthcare Materialsen_US

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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal