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dc.contributor.authorSnipstad, Sofie
dc.contributor.authorBerg, Sigrid
dc.contributor.authorMørch, Ýrr Asbjørg
dc.contributor.authorBjørkøy, Astrid
dc.contributor.authorSulheim, Einar
dc.contributor.authorHansen, Rune
dc.contributor.authorGrimstad, Ingeborg
dc.contributor.authorvan Wamel, Annemieke
dc.contributor.authorMaaland, Astri Fjelde
dc.contributor.authorTorp, Sverre Helge
dc.contributor.authorDavies, Ruth Catharina de Lange
dc.date.accessioned2020-12-16T09:17:56Z
dc.date.available2020-12-16T09:17:56Z
dc.date.created2017-11-24T14:31:26Z
dc.date.issued2017
dc.identifier.citationUltrasound in Medicine and Biology. 2017, 43 (11), 2651-2669.en_US
dc.identifier.issn0301-5629
dc.identifier.urihttps://hdl.handle.net/11250/2719735
dc.description.abstractCompared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various biological barriers and uneven tumor perfusion. We investigated a unique multifunctional drug delivery system consisting of microbubbles stabilized by polymeric nanoparticles (NPMBs), enabling ultrasound-mediated drug delivery. The aim was to examine mechanisms of ultrasound-mediated delivery and to determine if increased tumor uptake had a therapeutic benefit. Cellular uptake and toxicity, circulation and biodistribution were characterized. After intravenous injection of NPMBs into mice, tumors were treated with ultrasound of various pressures and pulse lengths, and distribution of nanoparticles was imaged on tumor sections. No effects of low pressures were observed, whereas complete bubble destruction at higher pressures improved tumor uptake 2.3 times, without tissue damage. An enhanced therapeutic effect was illustrated in a promising proof-of-concept study, in which all tumors exhibited regression into complete remission.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/deed.no*
dc.titleUltrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenograftsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright: 2017 The Authors. Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biologyen_US
dc.source.pagenumber2651-2669en_US
dc.source.volume43en_US
dc.source.journalUltrasound in Medicine and Biologyen_US
dc.source.issue11en_US
dc.identifier.doi10.1016/j.ultrasmedbio.2017.06.029
dc.identifier.cristin1518203
cristin.unitcode7401,60,45,0
cristin.unitcode7401,80,1,4
cristin.unitcode7401,80,0,0
cristin.unitnameMedisinsk teknologi
cristin.unitnamePolymerpartikler og overflatekjemi
cristin.unitnameSINTEF Materialer og kjemi
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 Internasjonal