dc.contributor.author | Flobak, Åsmund | |
dc.contributor.author | Niederdorfer, Barbara | |
dc.contributor.author | To, Vu | |
dc.contributor.author | Thommesen, Liv | |
dc.contributor.author | Klinkenberg, Geir | |
dc.contributor.author | Lægreid, Astrid | |
dc.date.accessioned | 2020-01-03T13:56:26Z | |
dc.date.available | 2020-01-03T13:56:26Z | |
dc.date.created | 2019-11-26T08:36:44Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Scientific Data. 2019, 6 1-10. | nb_NO |
dc.identifier.issn | 2052-4463 | |
dc.identifier.uri | http://hdl.handle.net/11250/2634848 | |
dc.description.abstract | While there is a high interest in drug combinations in cancer therapy, openly accessible datasets for drug combination responses are sparse. Here we present a dataset comprising 171 pairwise combinations of 19 individual drugs targeting signal transduction mechanisms across eight cancer cell lines, where the effect of each drug and drug combination is reported as cell viability assessed by metabolic activity. Drugs are chosen by their capacity to specifically interfere with well-known signal transduction mechanisms. Signalling processes targeted by the drugs include PI3K/AKT, NFkB, JAK/STAT, CTNNB1/TCF, and MAPK pathways. Drug combinations are classified as synergistic based on the Bliss independence synergy metrics. The data identifies combinations that synergistically reduce cancer cell viability and that can be of interest for further pre-clinical investigations. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Nature | nb_NO |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.subject | Cancer therapy | nb_NO |
dc.subject | Signalling processes | nb_NO |
dc.subject | Cell lines | nb_NO |
dc.title | A high-throughput drug combination screen of targeted small molecule inhibitors in cancer cell lines | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | nb_NO |
dc.source.pagenumber | 1-10 | nb_NO |
dc.source.volume | 6 | nb_NO |
dc.source.journal | Scientific Data | nb_NO |
dc.identifier.doi | 10.1038/s41597-019-0255-7 | |
dc.identifier.cristin | 1752162 | |
cristin.unitcode | 7401,80,1,0 | |
cristin.unitname | Bioteknologi og nanomedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |