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dc.contributor.authorMyhren, Lene Elisabeth
dc.contributor.authorNygaard, Gyrid
dc.contributor.authorGausdal, Gro
dc.contributor.authorSletta, Håvard
dc.contributor.authorTeigen, Knut
dc.contributor.authorDegnes, Kristin Fløgstad
dc.contributor.authorZahlsen, Kolbjørn
dc.contributor.authorBrunsvik, Anders
dc.contributor.authorBruserud, Øystein
dc.contributor.authorDoskeland, Stein Ove
dc.contributor.authorSelheim, Frode
dc.contributor.authorHerfindal, Lars
dc.identifier.citationMarine Drugs 2013, 11(2):332-349nb_NO
dc.description.abstractDespite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a marine actinomycetes bacterium for the ability to induce cell death in a range of cell types. Iodinin showed selective toxicity to AML and acute promyelocytic (APL) leukemia cells, with EC50 values for cell death up to 40 times lower for leukemia cells when compared with normal cells. Iodinin also successfully induced cell death in patient-derived leukemia cells or cell lines with features associated with poor prognostic such as FLT3 internal tandem duplications or mutated/deficient p53. The cell death had typical apoptotic morphology, and activation of apoptotic signaling proteins like caspase-3. Molecular modeling suggested that iodinin could intercalate between bases in the DNA in a way similar to the anti-cancer drug daunorubicin (DNR), causing DNA-strand breaks. Iodinin induced apoptosis in several therapy-resistant AML-patient blasts, but to a low degree in peripheral blood leukocytes, and in contrast to DNR, not in rat cardiomyoblasts. The low activity towards normal cell types that are usually affected by anti-leukemia therapy suggests that iodinin and related compounds represent promising structures in the development of anti-cancer therapy.nb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.titleIodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cellsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.rights.holderThe Authorsnb_NO
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Onkologi: 762nb_NO
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Oncology: 762nb_NO
dc.source.journalMarine Drugsnb_NO

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