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Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2)

dc.contributor.authorWentzel, Alexander
dc.contributor.authorBruheim, Per
dc.contributor.authorØverby, Anders
dc.contributor.authorJakobsen, Øyvind Mejdell
dc.contributor.authorSletta, Håvard
dc.contributor.authorOmara, Walid A.M.
dc.contributor.authorHodgson, David A.
dc.contributor.authorEllingsen, Trond Erling
dc.date.accessioned2015-09-30T07:19:16Z
dc.date.accessioned2017-01-04T11:05:38Z
dc.date.available2015-09-30T07:19:16Z
dc.date.available2017-01-04T11:05:38Z
dc.date.issued2012
dc.identifier.citationBMC Systems Biology 2012, 6(59):1-16nb_NO
dc.identifier.issn1752-0509
dc.identifier.urihttp://hdl.handle.net/11250/2426255
dc.description-nb_NO
dc.description.abstractSystems biology approaches to study metabolic switching in Streptomyces coelicolor A3(2) depend on cultivation conditions ensuring high reproducibility and distinct phases of culture growth and secondary metabolite production. In addition, biomass concentrations must be sufficiently high to allow for extensive time-series sampling before occurrence of a given nutrient depletion for transition triggering. The present study describes for the first time the development of a dedicated optimized submerged batch fermentation strategy as the basis for highly time-resolved systems biology studies of metabolic switching in S. coelicolor A3(2).nb_NO
dc.language.isoengnb_NO
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleOptimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2)nb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.date.updated2015-09-30T07:19:16Z
dc.identifier.doi10.1186/1752-0509-6-59
dc.identifier.cristin944666


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