Blar i SINTEF Industri på forfatter "Zubarev, Roman A."

Viser treff 1-2 av 2

    • Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation 

      Visnes, Torkild; Armando, Cazares-Körner; Wenjing, Hao; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr; Astorga-Wells, Juan; Jemth, Ann-Sofie; Pan, Lang; Sanjiv, Kumar; Karsten, Stella; Gokturk, Camilla; Grube, Maurice; Evert J, Homan; Hanna, Bishoy Magdi Fekry; Cynthia, Paulin BJ; pham, Therese; Rasti, Azita; Warpman Berglund, Ulrika; von Nikolai, Catharina; Benitez-Buelga, Carlos; Koolmeister, Tobias; Ivanic, Dag; Iliev, Petar; Scobie, Martin; Krokan, Hans Einar; Baranczewski, Pawel; Artursson, Per; Altun, Mikael; Jenmalm-Jensen, Annika; Kalderen, Christina; Xueqing, Ba; Zubarev, Roman A.; Stenmark, Pål; Boldogh, Istvan; Helleday, Thomas (Journal article; Peer reviewed, 2018)
      The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and ...

    • Thermal proteome profiling identifies oxidative-dependent inhibition of the transcription of major oncogenes as a new therapeutic mechanism for select anticancer compounds 

      Peuget, Sylvain; Zhu, J; Sanz, Gema; Singh, Madhurendra; Gaetani, Massimiliano; Chen, Xinsong; Shi, Yao; Saei, Amir Ata; Visnes, Torkild; Lindström, Mikael; Rihani, A; Moyano-Galceran, Lidia; Carlson, Joseph W.; Hjerpe, Elisabeth; Joneborg, Ulrika; Lehti, Kaisa; Hartman, Johan; Helleday, Thomas; Zubarev, Roman A.; Selivanova, Galina (Peer reviewed; Journal article, 2020)
      Identification of the molecular mechanism of action (MoA) of bioactive compounds is a crucial step for drug development but remains a challenging task despite recent advances in technology. In this study, we applied ...