• Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1 

      Wallner, Olov; Cázares-Körner, Armando; Scaletti, Emma Rose; Masuyer, Geoffrey; Bekkhus, Tove; Visnes, Torkild; Mamonov, Kirill; Ortis, Florian; Lundbäck, Thomas; Volkova, Maria; Koolmeister, Tobias; Wiita, Elisée; Loseva, Olga; Pandey, Monica; Homan, Evert J.; Benítez-Buelga, Carlos; Davies, Jonathan; Scobie, Martin; Warpman Berglund, Ulrika; Kalderén, Christina; Stenmark, Pål; Helleday, Thomas; Michel, Maurice (Peer reviewed; Journal article, 2022)
      8-oxo Guanine DNA Glycosylase 1 is the initiating enzyme within base excision repair and removes oxidized guanines from damaged DNA. Since unrepaired 8-oxoG could lead to G : C→T : A transversion, base removal is of utmost ...