Blar i SINTEF Industri på forfatter "Olsen, Silje Malene"
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Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation
Schulz, Susann; Sletta, Håvard; Degnes, Kristin Fløgstad; Krysenko, Sergii; Williams, Alicia; Olsen, Silje Malene; Vernstad, Kai; Mitulski, Agnieszka; Wohlleben, Wolfgang (Peer reviewed; Journal article, 2023)FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological ...