Blar i SINTEF Open på forfatter "Van Wezel, Gilles P."
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A BioBricks Metabolic Engineering Platform for the Biosynthesis of Anthracyclinones in Streptomyces coelicolor
Wang, Rongbin; Nguyen, Jennifer; Hecht, Jacob; Schwartz, Nora; Brown, Katelyn V.; Ponomareva, Larissa V.; Niemczura, Magdalena; van Dissel, Dino; Van Wezel, Gilles P.; Thorson, Jon S.; Metsä-Ketelä, Mikko; Shaaban, Khaled A.; Nybo, S. Eric (Peer reviewed; Journal article, 2022)Actinomycetes produce a variety of clinically indispensable molecules, such as antineoplastic anthracyclines. However, the actinomycetes are hindered in their further development as genetically engineered hosts for the ... -
Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
Sulheim, Snorre; Kumelj, Tjasa; van Dissel, Dino; Salehzadeh-Yazdi, Ali; Chao, Du; Van Wezel, Gilles P.; Nieselt, Kay; Almaas, Eivind; Wentzel, Alexander; Kerkhoven, Eduard J (Peer reviewed; Journal article, 2020)Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host ...