Browsing SINTEF Open by Author "Widerøe, Marius"
Now showing items 1-3 of 3
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Contrast Enhanced Magnetic Resonance Imaging of Amyloid-β Plaques in a Murine Alzheimer's Disease Model
Sulheim, Einar; Widerøe, Marius; Bäck, Marcus; Nilsson, K Peter R; Hammarström, Per; Nilsson, Lars; Davies, Catharina de Lange; Åslund, Karl Olof Andreas (Peer reviewed; Journal article, 2023)Background: Early detection of amyloid-β (Aβ) aggregates is a critical step to improve the treatment of Alzheimer’s disease (AD) because neuronal damage by the Aβ aggregates occurs before clinical symptoms are apparent. ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Peer reviewed; Journal article, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Perfusion system for studying dynamic metabolomics in rat brain slices exposed to oxygen–glucose deprivation using proton and phosphorus nuclear magnetic resonance
Molska, Alicja Anna; Hill, Deborah Katherine; Andreassen, Trygve; Widerøe, Marius (Peer reviewed; Journal article, 2022)The aim of the current study was to establish a controlled and reproducible model to study metabolic changes during oxygen–glucose deprivation (OGD) in rat brain using a nuclear magnetic resonance (NMR)-compatible perfusion ...