• Butanol production from lignocellulosic sugars by Clostridium beijerinckii in microbioreactors 

      Birgen, Cansu; Degnes, Kristin Fløgstad; Markussen, Sidsel; Wentzel, Alexander; Sletta, Håvard (Peer reviewed; Journal article, 2021)
      Butanol (n-butanol) has been gaining attention as a renewable energy carrier and an alternative biofuel with superior properties to the most widely used ethanol. We performed 48 anaerobic fermentations simultaneously with ...
    • Bærekraftig fôr til norsk laks 

      Gjøsund, Svein Helge; Skjermo, Jorunn; Forbord, Silje; Jafarzadeh, Sepideh; Sletta, Håvard; Aasen, Inga Marie; Hagemann, Andreas; Chauton, Matilde Skogen; Aursand, Ida Grong; Evjemo, Jan Ove; Slizyte, Rasa; Standal, Inger Beate; Grimsmo, Leif; Aursand, Marit; Josefsen, Kjell Domaas; Almås, Karl Andreas (SINTEF rapporter;2020:01128 A, Research report, 2020-11-02)
      I rapporten er 23 ulike råvarer vurdert ut fra tre kriterier: • Hvor mye råvare kan være tilgjengelig? • Kan råvaren bidra til å dekke det framtidige behovet for protein og EPA/DHA? • Kan dette fremskaffes på en bærekraftig ...
    • Chitosan as a wound dressing starting material: antimicrobial Properties and mode of action 

      Matica, Mariana Adina; Aachmann, Finn Lillelund; Tøndervik, Anne; Sletta, Håvard; Ostafe, Vasile (Peer reviewed; Journal article, 2019)
      Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes ...
    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...
    • Engineering chitinolytic activity into a cellulose-active lytic polysaccharide monooxygenase provides insights into substrate specificity 

      Jensen, Marianne Slang; Klinkenberg, Geir; Bissaro, Bastien; Chylenski, Piotr; Vaaje-Kolstad, Gustav; Kvitvang, Hans Fredrik Nyvold; Nærdal, Guro Kruge; Sletta, Håvard; Forsberg, Zarah; Eijsink, Vincent (Journal article; Peer reviewed, 2019)
      Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative cleavage of recalcitrant polysaccharides such as cellulose and chitin and play an important role in the enzymatic degradation of biomass. While it is clear ...
    • Identification of a Pivotal Residue for Determining the Block Structure-Forming Properties of Alginate C-5 Epimerases 

      Stanisci, Annalucia; Tøndervik, Anne; Gaardløs, Margrethe; Lervik, Anders; Skjåk-Bræk, Gudmund; Sletta, Håvard; Aachmann, Finn Lillelund (Peer reviewed; Journal article, 2020)
      Alginate is a linear copolymer composed of 1→4 linked β-d-mannuronic acid (M) and its epimer α-l-guluronic acid (G). The polysaccharide is first produced as homopolymeric mannuronan and subsequently, at the polymer level, ...
    • Identification of Regulatory Genes and Metabolic Processes Important for Alginate Biosynthesis in Azotobacter vinelandii by Screening of a Transposon Insertion Mutant Library 

      Mærk, Mali; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Klinkenberg, Geir; Tøndervik, Anne; Ellingsen, Trond Erling; Valla, Svein; Ertesvåg, Helga (Peer reviewed; Journal article, 2020)
      Azotobacter vinelandii produces the biopolymer alginate, which has a wide range of industrial and pharmaceutical applications. A random transposon insertion mutant library was constructed from A. vinelandii ATCC12518Tc in ...
    • Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor 

      Wentzel, Alexander; Sletta, Håvard; Wellington, E.M.H.; Ellingsen, Trond Erling; Bruheim, Per (Journal article; Peer reviewed, 2012)
      A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring as strains of S. ...
    • Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells 

      Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Journal article; Peer reviewed, 2013)
      Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ...
    • Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling 

      Borgos, Sven Even F.; Bordel, Sergio; Sletta, Håvard; Ertesvåg, Helga; Jakobsen, Øyvind Mejdell; Bruheim, Per; Ellingsen, Trond Erling; Nielsen, Jens; Valla, Svein (Journal article; Peer reviewed, 2013)
      Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to the genera ...
    • Nye muligheter for verdiskaping i Norge 

      Størseth, Trond Røvik; Kaspersen, Jon Harald; Størseth, Trond Røvik; Kaspersen, Jon Harald; Sletta, Håvard; Skjermo, Jorunn; Hagemann, Andreas; Sheridan, Edel; Røkke, Nils; Sørum, Lars; Shmueli, Andrea; Rødseth, Ørnulf J.; Kvamstad-Lervold, Beate; Lødeng, Rune; Tschentscher, Roman; Bjørgen, Astrid; Heyn, Richard; Dahl, Nina; Ringdalen, Eli; Hovland, Jon; Helness, Herman; Handå, Aleksander; Grande, Carlos A.; Wærnes, Ole; Høgaas, Per Helge; Alnæs, Lisbeth; Eidem, Per A.; Røkke, Nils; Bruaset, Stian; Sivertsen, Edvard; Rüther, Petra; Time, Berit; Slapø, Fredrik (SINTEF rapporter;, Research report, 2019-08)
      Denne rapporten er levert av SINTEF på oppdrag fra NHO. Den er en del av et større utredningsarbeid – «Veikart for fremtidens næringsliv». I dette arbeidet deltar SINTEF med beskrivelser og analyser knyttet til sentrale ...
    • Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2) 

      Wentzel, Alexander; Bruheim, Per; Øverby, Anders; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Omara, Walid A.M.; Hodgson, David A.; Ellingsen, Trond Erling (Journal article; Peer reviewed, 2012)
      Systems biology approaches to study metabolic switching in Streptomyces coelicolor A3(2) depend on cultivation conditions ensuring high reproducibility and distinct phases of culture growth and secondary metabolite production. ...
    • Overall size of mannuronan C5-Epimerases influences their ability to epimerize modified alginates and alginate gels 

      Stanisci, Annalucia; Aarstad, Olav Andreas; Tøndervik, Anne; Sletta, Håvard; Dypås, Lene Brattsti; Skjåk-Bræk, Gudmund; Aachmann, Finn Lillelund (Peer reviewed; Journal article, 2018)
      A family of seven mannuronan C5-epimerases (AlgE1-AlgE7) produced by Azotobacter vinelandii is able to convert β-d-mannuronate (M) to its epimer α-l-guluronate (G) in alginates. Even sharing high sequence homology at the ...
    • The Use of Extracellular Membrane Vesicles for Immunization against Francisellosis in Nile Tilapia (Oreochromis niloticus) and Atlantic cod (Gadus morhua L.) 

      Mertes, Verena; Kashulin, Alexander; Lagos, Leidy; Ciani, Elia; Colquhoun, Duncan John; Haslene-Hox, Hanne; Sletta, Håvard; Sørum, Henning; Winther-Larsen, Hanne Cecilie (Peer reviewed; Journal article, 2021)
      Francisellosis in fish is caused by the facultative intracellular Gram-negative bacterial pathogens Francisella noatunensis ssp. noatunensis and Francisella orientalis. The disease is affecting both farmed and wild fish ...