• Butanol production from lignocellulosic sugars by Clostridium beijerinckii in microbioreactors 

      Birgen, Cansu; Degnes, Kristin Fløgstad; Markussen, Sidsel; Wentzel, Alexander; Sletta, Håvard (Peer reviewed; Journal article, 2021)
      Butanol (n-butanol) has been gaining attention as a renewable energy carrier and an alternative biofuel with superior properties to the most widely used ethanol. We performed 48 anaerobic fermentations simultaneously with ...
    • Bærekraftig fôr til norsk laks 

      Almås, Karl Andreas; Josefsen, Kjell Domaas; Gjøsund, Svein Helge; Skjermo, Jorunn; Forbord, Silje; Jafarzadeh, Sepideh; Sletta, Håvard; Aasen, Inga Marie; Hagemann, Andreas; Chauton, Matilde Skogen; Aursand, Ida Grong; Evjemo, Jan Ove; Slizyte, Rasa; Standal, Inger Beate; Grimsmo, Leif; Aursand, Marit (SINTEF rapporter;2020:01128 A, Research report, 2020-11-02)
      I rapporten er 23 ulike råvarer vurdert ut fra tre kriterier: • Hvor mye råvare kan være tilgjengelig? • Kan råvaren bidra til å dekke det framtidige behovet for protein og EPA/DHA? • Kan dette fremskaffes på en bærekraftig ...
    • Characterization of Microbial Diversity in Decayed Wood from a Spanish Forest: An Environmental Source of Industrially Relevant Microorganisms 

      Velasco-Rodríguez, Óscar; Fil, Mariana; Heggeset, Tonje Marita Bjerkan; Degnes, Kristin Fløgstad; Becerro-Recio, David; Kolsaková, Katarina; Haugen, Tone; Jønsson, Malene; Toral-Martínez, Macarena; García-Estrada, Carlos; Sola-Landa, Alberto; Josefsen, Kjell Domaas; Sletta, Håvard; Barreiro, Carlos (Peer reviewed; Journal article, 2022)
      Rotting wood is inhabited by a large diversity of bacteria, fungi, and insects with complex environmental relationships. The aim of this work was to study the composition of the microbiota (bacteria and fungi) in decaying ...
    • Chitosan as a wound dressing starting material: antimicrobial Properties and mode of action 

      Matica, Mariana Adina; Aachmann, Finn Lillelund; Tøndervik, Anne; Sletta, Håvard; Ostafe, Vasile (Peer reviewed; Journal article, 2019)
      Fighting bacterial resistance is one of the concerns in modern days, as antibiotics remain the main resource of bacterial control. Data shows that for every antibiotic developed, there is a microorganism that becomes ...
    • Cytotoxicity of poly(Alkyl cyanoacrylate) nanoparticles 

      Sulheim, Einar; Iversen, Tore Geir; To, Vu; Klinkenberg, Geir; Sletta, Håvard; Schmid, Ruth; Hatletveit, Anne Rein; Wågbø, Ane Marit; Sundan, Anders; Skotland, Tore; Sandvig, Kirsten; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2017)
      Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis of one cell line only. Cytotoxicity of nanoparticles is complex and should, preferentially, be evaluated ...
    • Engineering chitinolytic activity into a cellulose-active lytic polysaccharide monooxygenase provides insights into substrate specificity 

      Jensen, Marianne Slang; Klinkenberg, Geir; Bissaro, Bastien; Chylenski, Piotr; Vaaje-Kolstad, Gustav; Kvitvang, Hans Fredrik Nyvold; Nærdal, Guro Kruge; Sletta, Håvard; Forsberg, Zarah; Eijsink, Vincent (Journal article; Peer reviewed, 2019)
      Lytic polysaccharide monooxygenases (LPMOs) catalyze oxidative cleavage of recalcitrant polysaccharides such as cellulose and chitin and play an important role in the enzymatic degradation of biomass. While it is clear ...
    • Exploiting mannuronan C-5 epimerases in commercial alginate production 

      Tøndervik, Anne; Aarstad, Olav Andreas; Aune, Randi; Maleki, Susan; Rye, Philip D; Dessen, Arne; Skjåk-Bræk, Gudmund; Sletta, Håvard (Peer reviewed; Journal article, 2020)
    • Farmed salmon rest raw materials as a source of peptones for industrial fermentation media 

      Broli, Gunn; Nygaard, Halvor; Sletta, Håvard; Sandnes, Kjartan; Aasen, Inga Marie (Peer reviewed; Journal article, 2020)
      Twelve marine peptones prepared from rest raw materials (RRM) from farmed salmon have been evaluated as nutrient sources in growth media for industrial microorganisms. The peptones were prepared from head and backbones, ...
    • High-throughput assay for effect screening of amphotericin B and bioactive components on filamentous Candida albicans 

      Haslene-Hox, Hanne; Nærdal, Guro Kruge; Mørch, Ýrr Asbjørg; Hageskal, Gunhild; Tøndervik, Anne; Vikenes, Anette; Johnsen, Heidi; Klinkenberg, Geir; Sletta, Håvard (Peer reviewed; Journal article, 2022)
    • Hvordan styrke SFI-enes bidrag til innovasjon? 

      Henriksen, Partow Pakdel; Nisja, Ragnhild; Størkersen, Kristine Vedal; Wærnes, Aud Nina; Sletta, Håvard; Haug, Kaja Kristine; Måsøy, Svein-Erik; Langseth, Magnus; Henriksen, Ottar; Skjølsvik, Kjell Olav (Research report, 2023)
    • Identification of a Pivotal Residue for Determining the Block Structure-Forming Properties of Alginate C-5 Epimerases 

      Stanisci, Annalucia; Tøndervik, Anne; Gaardløs, Margrethe; Lervik, Anders; Skjåk-Bræk, Gudmund; Sletta, Håvard; Aachmann, Finn Lillelund (Peer reviewed; Journal article, 2020)
      Alginate is a linear copolymer composed of 1→4 linked β-d-mannuronic acid (M) and its epimer α-l-guluronic acid (G). The polysaccharide is first produced as homopolymeric mannuronan and subsequently, at the polymer level, ...
    • Identification of Regulatory Genes and Metabolic Processes Important for Alginate Biosynthesis in Azotobacter vinelandii by Screening of a Transposon Insertion Mutant Library 

      Mærk, Mali; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Klinkenberg, Geir; Tøndervik, Anne; Ellingsen, Trond Erling; Valla, Svein; Ertesvåg, Helga (Peer reviewed; Journal article, 2020)
      Azotobacter vinelandii produces the biopolymer alginate, which has a wide range of industrial and pharmaceutical applications. A random transposon insertion mutant library was constructed from A. vinelandii ATCC12518Tc in ...
    • Intracellular metabolite pool changes in response to nutrient depletion induced metabolic switching in Streptomyces coelicolor 

      Wentzel, Alexander; Sletta, Håvard; Wellington, E.M.H.; Ellingsen, Trond Erling; Bruheim, Per (Journal article; Peer reviewed, 2012)
      A metabolite profiling study of the antibiotic producing bacterium Streptomyces coelicolor A3(2) has been performed. The aim of this study was to monitor intracellular metabolite pool changes occurring as strains of S. ...
    • Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells 

      Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Journal article; Peer reviewed, 2013)
      Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ...
    • Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling 

      Borgos, Sven Even F.; Bordel, Sergio; Sletta, Håvard; Ertesvåg, Helga; Jakobsen, Øyvind Mejdell; Bruheim, Per; Ellingsen, Trond Erling; Nielsen, Jens; Valla, Svein (Journal article; Peer reviewed, 2013)
      Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to the genera ...
    • Nye muligheter for verdiskaping i Norge 

      Størseth, Trond Røvik; Kaspersen, Jon Harald; Størseth, Trond Røvik; Kaspersen, Jon Harald; Sletta, Håvard; Skjermo, Jorunn; Hagemann, Andreas; Sheridan, Edel; Røkke, Nils; Sørum, Lars; Shmueli, Andrea; Rødseth, Ørnulf J.; Kvamstad-Lervold, Beate; Lødeng, Rune; Tschentscher, Roman; Bjørgen, Astrid; Heyn, Richard; Dahl, Nina; Ringdalen, Eli; Hovland, Jon; Helness, Herman; Handå, Aleksander; Grande, Carlos A.; Wærnes, Ole; Høgaas, Per Helge; Alnæs, Lisbeth; Eidem, Per A.; Røkke, Nils; Bruaset, Stian; Sivertsen, Edvard; Rüther, Petra; Time, Berit; Slapø, Fredrik (SINTEF rapporter;, Research report, 2019-08)
      Denne rapporten er levert av SINTEF på oppdrag fra NHO. Den er en del av et større utredningsarbeid – «Veikart for fremtidens næringsliv». I dette arbeidet deltar SINTEF med beskrivelser og analyser knyttet til sentrale ...
    • Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation 

      Schulz, Susann; Sletta, Håvard; Degnes, Kristin Fløgstad; Krysenko, Sergii; Williams, Alicia; Olsen, Silje Malene; Vernstad, Kai; Mitulski, Agnieszka; Wohlleben, Wolfgang (Peer reviewed; Journal article, 2023)
      FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological ...
    • Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2) 

      Wentzel, Alexander; Bruheim, Per; Øverby, Anders; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Omara, Walid A.M.; Hodgson, David A.; Ellingsen, Trond Erling (Journal article; Peer reviewed, 2012)
      Systems biology approaches to study metabolic switching in Streptomyces coelicolor A3(2) depend on cultivation conditions ensuring high reproducibility and distinct phases of culture growth and secondary metabolite production. ...
    • Overall size of mannuronan C5-Epimerases influences their ability to epimerize modified alginates and alginate gels 

      Stanisci, Annalucia; Aarstad, Olav Andreas; Tøndervik, Anne; Sletta, Håvard; Dypås, Lene Brattsti; Skjåk-Bræk, Gudmund; Aachmann, Finn Lillelund (Peer reviewed; Journal article, 2018)
      A family of seven mannuronan C5-epimerases (AlgE1-AlgE7) produced by Azotobacter vinelandii is able to convert β-d-mannuronate (M) to its epimer α-l-guluronate (G) in alginates. Even sharing high sequence homology at the ...
    • Strain Construction and Process Development for Efficient Recombinant Production of Mannuronan C-5 Epimerases in Hansenula polymorpha 

      Tøndervik, Anne; Aune, Randi; Degelmann, Adelheid; Piontek, Michael; Ertesvåg, Helga; Skjåk-Bræk, Gudmund; Sletta, Håvard (Peer reviewed; Journal article, 2022)
      Alginates are linear polysaccharides produced by brown algae and some bacteria and are composed of β-D-mannuronic acid (M) and α-L-guluronic acid (G). Alginate has numerous present and potential future applications within ...