Browsing SINTEF Open by Author "Mehn, Dora"
Now showing items 1-7 of 7
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2020)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Detection, counting and characterization of nanoplastics in marine bioindicators: a proof of principle study.
Valsesia, Andrea; Parot, Jérémie; Ponti, Jessica; Mehn, Dora; Marino, Rita; Melillo, Daniela; Muramoto, Shin; Verkouteren, Mike; Hackley, Vincent A.; Colpo, Pascal (Peer reviewed; Journal article, 2021)Plastic particulates in the environment pose an increasing concern for regulatory bodies due to their potential risk to higher organisms (including humans) as they enter the food chain. Nanoplastics (defined here as smaller ... -
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?
Vogel, Robert; Savage, John; Muzard, Julien; Camera, Giacomo Della; Vella, Gabriele; Law, Alice; Marchioni, Marianne; Mehn, Dora; Geiss, Otmar; Peacock, Ben; Aubert, Dimitri; Calzolai, Luigi; Caputo, Fanny; Prina-Mello, Adriele (Peer reviewed; Journal article, 2021)The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation ... -
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
Caputo, Fanny; Vogel, R.; Savage, J.; Vella, G.; Law, A.; Della Camera, Camera; Hannon, G.; Peacock, B.; Mehn, Dora; Ponti, J.; Geiss, Otmar; Aubert, D.; Prina-Mello, Adriele; Calzolai, Luigi (Peer reviewed; Journal article, 2021)HYPOTHESIS:The implementation of the proposal from the European Chemical Agency (ECHA) to restrict the use of nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods to perform size and ... -
Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods
Huber, Maximilian J.; Ivleva, Natalia P.; Booth, Andy; Beer, Irina; Bianchi, Ivana; Drexel, Roland; Geiss, Otmar; Mehn, Dora; Meier, Florian; Molska, Alicja Anna; Parot, Jérémie; Sørensen, Lisbet; Vella, Gabriele; Prina‑Mello, Adriele; Vogel, Robert; Caputo, Fanny (Peer reviewed; Journal article, 2023)A comprehensive physicochemical characterization of heterogeneous nanoplastic (NPL) samples remains an analytical challenge requiring a combination of orthogonal measurement techniques to improve the accuracy and robustness ... -
Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques
Parot, Jérémie; Mehn, Dora; Jankevics-Jones, Hanna; Markova, Natalia; Carboni, Michele; Olaisen, Camilla; Hoel, Andrea Draget; Sigfúsdóttir, Margrét S.; Meier, Florian; Drexel, Roland; Vella, Gabriella; Mcdonagh, Birgitte Hjelmeland; Hansen, Terkel; Bui, Huong; Klinkenberg, Geir; Visnes, Torkild; Gioria, Sabrina; Urban-Lopez, Patricia; Prina-Mello, Adriele; Borgos, Sven Even F.; Caputo, Fanny; Calzolai, Luigi (Peer reviewed; Journal article, 2024)The availability of analytical methods for the characterization of lipid nanoparticles (LNPs) for in-vivo intracellular delivery of nucleic acids is critical for the fast development of innovative RNA therapies. In this ...