Blar i SINTEF Open på forfatter "Degnes, Kristin Fløgstad"
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A new and improved host-independent plasmid system for RK2-based conjugal transfer
Aakvik, Trine; Lale, Rahmi; Degnes, Kristin Fløgstad; Lando, Malin; Valla, Svein (Journal article, 2014)Bacterial conjugation is a process that is mediated either by a direct cell-to-cell junction or by formation of a bridge between the cells. It is often used to transfer DNA constructs designed in Escherichia coli to recipient ... -
Butanol production from lignocellulosic sugars by Clostridium beijerinckii in microbioreactors
Birgen, Cansu; Degnes, Kristin Fløgstad; Markussen, Sidsel; Wentzel, Alexander; Sletta, Håvard (Peer reviewed; Journal article, 2021)Butanol (n-butanol) has been gaining attention as a renewable energy carrier and an alternative biofuel with superior properties to the most widely used ethanol. We performed 48 anaerobic fermentations simultaneously with ... -
Characterization of Microbial Diversity in Decayed Wood from a Spanish Forest: An Environmental Source of Industrially Relevant Microorganisms
Velasco-Rodríguez, Óscar; Fil, Mariana; Heggeset, Tonje Marita Bjerkan; Degnes, Kristin Fløgstad; Becerro-Recio, David; Kolsaková, Katarina; Haugen, Tone; Jønsson, Malene; Toral-Martínez, Macarena; García-Estrada, Carlos; Sola-Landa, Alberto; Josefsen, Kjell Domaas; Sletta, Håvard; Barreiro, Carlos (Peer reviewed; Journal article, 2022)Rotting wood is inhabited by a large diversity of bacteria, fungi, and insects with complex environmental relationships. The aim of this work was to study the composition of the microbiota (bacteria and fungi) in decaying ... -
Condensed tannins, novel compounds and sources of variation determine the antiparasitic activity of Nordic conifer bark against gastrointestinal nematodes
Chylinski, Caroline; Degnes, Kristin Fløgstad; Aasen, Inga Marie; Ptochos, Sokratis; Blomstrand, Berit Marie; Mahnert, Karl-Christian; Enemark, Heidi L; Thamsborg, Stig Milan; Steinshamn, Håvard; Athanasiadou, Spiridoula (Peer reviewed; Journal article, 2023)The antiparasitic potential of plants could offer a vital solution to alleviating the costs of gastrointestinal nematode (GIN) infections in ruminant production globally. Leveraging known bioactive molecules, however, is ... -
Iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from streptosporangium sp. induces apoptosis selectively in myeloid leukemia cell lines and patient cells
Myhren, Lene Elisabeth; Nygaard, Gyrid; Gausdal, Gro; Sletta, Håvard; Teigen, Knut; Degnes, Kristin Fløgstad; Zahlsen, Kolbjørn; Brunsvik, Anders; Bruserud, Øystein; Doskeland, Stein Ove; Selheim, Frode; Herfindal, Lars (Journal article; Peer reviewed, 2013)Despite recent improvement in therapy, acute myeloid leukemia (AML) is still associated with high lethality. In the presented study, we analyzed the bioactive compound iodinin (1,6-dihydroxyphenazine 5,10-dioxide) from a ... -
Optimization of FK-506 production in Streptomyces tsukubaensis by modulation of Crp-mediated regulation
Schulz, Susann; Sletta, Håvard; Degnes, Kristin Fløgstad; Krysenko, Sergii; Williams, Alicia; Olsen, Silje Malene; Vernstad, Kai; Mitulski, Agnieszka; Wohlleben, Wolfgang (Peer reviewed; Journal article, 2023)FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological ... -
Streptomyces tardus sp. nov.: A Slow-Growing Actinobacterium Producing Candicidin, Isolated From Sediments of the Trondheim Fjord
Králová, Stanislava; Sandoval-Powers, Megan; Fawwal, Dorelle V.; Degnes, Kristin Fløgstad; Lewin, Anna; Klinkenberg, Geir; Nguyen, Giang-Son; Liles, Mark R.; Wentzel, Alexander (Peer reviewed; Journal article, 2021)Marine environments are home to an extensive number of microorganisms, many of which remain unexplored for taxonomic novelty and functional capabilities. In this study, a slow-growing Streptomyces strain expressing unique ...