Browsing SINTEF Open by Author "Borgos, Sven Even F."
Now showing items 1-20 of 21
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2020)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Bridging communities in the field of nanomedicine
Halamoda-Kenzaoui, Blanka; Baconnier, Simon; Bastogne, Thierry; Bazile, Didier; Boisseau, Patrick; Borchard, Gerrit; Borgos, Sven Even F.; Calzolai, Luigi; Cederbrant, Karin; Di Felice, Gabriella; Di Francesco, Tiziana; Dobrovolskaia, Marina A.; Gaspar, Rogério; Gracia, Belén; Hackley, Vincent A.; Leyens, Lada; Liptrott, Neill; Park, Margriet; Patri, Anil; Roebben, Gert; Roesslein, Matthias; Thürmer, René; Urbán, Patricia; Zuang, Valérie; Bremer-Hoffmann, Susanne (Journal article; Peer reviewed, 2019)An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality and safety requirements for these innovative health products. In order to stimulate interactions between ... -
Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft.
Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F.; Kildal, Wanja; Snipstad, Sofie; Sulheim, Einar; Fleten, Karianne Giller; Askautrud, Hanne Arenberg; Engebraaten, Olav; Flatmark, Kjersti; Iversen, Tore Geir; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Peer reviewed, 2018) -
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
Cryo-XPS for Surface Characterization of Nanomedicines
Cant, David J H; Pei, Yiwen; Shchukarev, Andrey; Ramstedt, Madeleine; Marques, Sara S.; Segundo, Marcela A.; Parot, Jérémie; Molska, Alicja Anna; Borgos, Sven Even F.; Shard, Alexander G.; Minelli, Caterina (Peer reviewed; Journal article, 2023)Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative ... -
A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS
Zabeo, Alex; Rosada, Fabio; Pizzol, Lisa; Caputo, Fanny; Borgos, Sven Even F.; Parot, Jérémie; Geertsma, Robert; Pouw, Joost Jacob; Vandebriel, Rob J.; Moreno, Oihane Ibarrola; Hristozov, Danail (Peer reviewed; Journal article, 2022)The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic ... -
Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
Hammond, Suzan M.; Aartsma-Rus, Annemieke; Alves, Sandra; Borgos, Sven Even F.; Buijsen, Ronald A.M; Collin, Rob W.J.; Covello, Giuseppina; Denti, Michela A.; Desviat, Lourdes R.; Echevarria, Lucia; Foged, Camilla; Gaina, Gisela; Garanto, Alejandro; Goyenvalle, Aurelie T.; Guzowska, Magdalena; Holodnuka, Irina; Jones, David R.; Krause, Sabine; Lehto, Taavi; Montolio, Marisol; Van Roon-Mom, Willeke; Arechavala-Gomeza, Virginia (Peer reviewed; Journal article, 2021)Nucleic acid-based therapeutics that regulate gene expression have been developed towards clinical use at a steady pace for several decades, but in recent years the field has been accelerating. To date, there are 11 marketed ... -
High-throughput synthesis and characterization of next-generation lipid nanoparticles for enhanced in vivo performance
Nelson, Bryant C.; Borgos, Sven Even F. (Journal article, 2022) -
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
Mildner, Robert; Hak, Sjoerd; Parot, Jeremie; Hyldbakk, Astrid; Borgos, Sven Even F.; some, dan; Johann, Cristoph; Caputo, Fanny (Peer reviewed; Journal article, 2021)Lipid-based nanoparticles for RNA delivery (LNP-RNA) are revolutionizing the nanomedicine field, with one approved gene therapy formulation and two approved vaccines against COVID-19, as well as multiple ongoing clinical ... -
In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate
Sonzini, Silvia; Caputo, Fanny; Mehn, Dora; Calzolai, Luigi; Borgos, Sven Even F.; Hyldbakk, Astrid; Treacher, Kevin; Li, Weimin; Jackman, Mark; Mahmoudi, Najet; Lawrence, M. Jayne; Patterson, Claire; Owen, David; Ashford, Marianne B; Akhtar, Nadim (Peer reviewed; Journal article, 2023)A deep and detailed understanding of drug-dendrimer conjugates key properties is needed to define the critical quality attributes that affect drug product performance. The characterization must be executed both in the ... -
Mapping global effects of the anti-sigma factor MucA in Pseudomonas fluorescens SBW25 through genome-scale metabolic modeling
Borgos, Sven Even F.; Bordel, Sergio; Sletta, Håvard; Ertesvåg, Helga; Jakobsen, Øyvind Mejdell; Bruheim, Per; Ellingsen, Trond Erling; Nielsen, Jens; Valla, Svein (Journal article; Peer reviewed, 2013)Alginate is an industrially important polysaccharide, currently produced commercially by harvesting of marine brown sea-weeds. The polymer is also synthesized as an exo-polysaccharide by bacteria belonging to the genera ... -
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation
Halamoda-Kenzaoui, Blanka; Vandebriel, Rob; Howarth, Alice; Siccardi, Marco; David, Chris; Liptrott, Neill; Santin, Marco; Borgos, Sven Even F.; Bremer-Hoffmann, Susanne; Caputo, Fanny (Peer reviewed; Journal article, 2021)Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available ... -
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation
Halamoda-Kenzaoui, Blanka; Vandebriel, Rob; Howarth, Alice; Siccardi, Marco; David, Chris; Liptrott, Neill; Santin, Marco; Borgos, Sven Even F.; Bremer-Hoffmann, Susanne; Caputo, Fanny (Peer reviewed; Journal article, 2021)Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available ... -
Orthogonal and complementary measurements of properties of drug products containing nanomaterials
Simon, Carl; Borgos, Sven Even F.; Calzolai, Luigi; Nelson, Bryant C.; Parot, Jérémie; Petersen, Elijah. J; Rösslein, Matthias; Xu, Xiaoming; Caputo, Fanny (Peer reviewed; Journal article, 2023)Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical quality attributes (CQAs). The task becomes particularly challenging ... -
Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances
Minnema, Jordi; Borgos, Sven Even F.; Liptrott, Neill; Vandebriel, Rob J.; Delmaar, Christiaan (Peer reviewed; Journal article, 2022)The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and parametrize a physiologically ... -
Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques
Parot, Jérémie; Mehn, Dora; Jankevics-Jones, Hanna; Markova, Natalia; Carboni, Michele; Olaisen, Camilla; Hoel, Andrea Draget; Sigfúsdóttir, Margrét S.; Meier, Florian; Drexel, Roland; Vella, Gabriella; Mcdonagh, Birgitte Hjelmeland; Hansen, Terkel; Bui, Huong; Klinkenberg, Geir; Visnes, Torkild; Gioria, Sabrina; Urban-Lopez, Patricia; Prina-Mello, Adriele; Borgos, Sven Even F.; Caputo, Fanny; Calzolai, Luigi (Peer reviewed; Journal article, 2024)The availability of analytical methods for the characterization of lipid nanoparticles (LNPs) for in-vivo intracellular delivery of nucleic acids is critical for the fast development of innovative RNA therapies. In this ... -
Regulatory guidelines and preclinical tools to study the biodistribution of RNA therapeutics
Vervaeke, P.; Borgos, Sven Even F.; Sanders, N.N.; Combes, Francis (Peer reviewed; Journal article, 2022)The success of the messenger RNA-based COVID-19 vaccines of Moderna and Pfizer/BioNTech marks the beginning of a new chapter in modern medicine. However, the rapid rise of mRNA therapeutics has resulted in a regulatory ... -
Relationship between polarities of antibiotic and polymer matrix on nanoparticle formulations based on aliphatic polyesters
Ritsma, Jeffrey; Herschberg, E.M.A.; Borgos, Sven Even F.; Løvmo, Cathrine; Schmid, Ruth; Welscher, Y.M te; Storm, Gert; Nostrum, C.F. van (Journal article; Peer reviewed, 2017) -
Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model
Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Peer reviewed; Journal article, 2019)Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ...