Blar i SINTEF Open på forfatter "Hyldbakk, Astrid"
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Alginate Microsphere Encapsulation of Drug-Loaded Nanoparticles: A Novel Strategy for Intraperitoneal Drug Delivery
Fleten, Karianne Giller; Hyldbakk, Astrid; Einen, Caroline; Benjakul, Sopisa; Strand, Berit Løkensgard; Davies, Catharina de Lange; Mørch, Ýrr Asbjørg; Flatmark, Kjersti (Peer reviewed; Journal article, 2022)Alginate hydrogels have been broadly investigated for use in medical applications due to their biocompatibility and the possibility to encapsulate cells, proteins, and drugs. In the treatment of peritoneal metastasis, rapid ... -
Biotransformation in water and soil of nitrosamines and nitramines potentially generated from amine-based CO2 capture technology
Brakstad, Odd Gunnar; Sørensen, Lisbet; Zahlsen, Kolbjørn; Bonaunet, Kristin; Hyldbakk, Astrid; Booth, Andy (Journal article; Peer reviewed, 2018-03)Nitrosamines (NSAs) and nitramines (NAs) are identified as possible degradation products from amine-based post-combustion CO2-capture (PCCC). Selected NSAs and NAs were subjected to aerobic and anaerobic biodegradation ... -
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
Identification of novel cyanoacrylate monomers for use in nanoparticle drug delivery systems prepared by miniemulsion polymerisation – A multistep screening approach
Hyldbakk, Astrid; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Klinkenberg, Geir; Nakstad, Vu; Wågbø, Ane Marit; Schmid, Ruth Baumberger; Molesworth, Peter Patrick (Peer reviewed; Journal article, 2022)Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in drug delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most ... -
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
Mildner, Robert; Hak, Sjoerd; Parot, Jeremie; Hyldbakk, Astrid; Borgos, Sven Even F.; some, dan; Johann, Cristoph; Caputo, Fanny (Peer reviewed; Journal article, 2021)Lipid-based nanoparticles for RNA delivery (LNP-RNA) are revolutionizing the nanomedicine field, with one approved gene therapy formulation and two approved vaccines against COVID-19, as well as multiple ongoing clinical ... -
In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate
Sonzini, Silvia; Caputo, Fanny; Mehn, Dora; Calzolai, Luigi; Borgos, Sven Even F.; Hyldbakk, Astrid; Treacher, Kevin; Li, Weimin; Jackman, Mark; Mahmoudi, Najet; Lawrence, M. Jayne; Patterson, Claire; Owen, David; Ashford, Marianne B; Akhtar, Nadim (Peer reviewed; Journal article, 2023)A deep and detailed understanding of drug-dendrimer conjugates key properties is needed to define the critical quality attributes that affect drug product performance. The characterization must be executed both in the ... -
Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models
Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Davies, Catharina de Lange; Flatmark, Kjersti; Mørch, Ýrr Asbjørg (Peer reviewed; Journal article, 2023)Colorectal and ovarian cancers frequently develop peritoneal metastases with few treatment options. Intraperitoneal chemotherapy has shown promising therapeutic effects, but is limited by rapid drug clearance and systemic ... -
Ultrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Model
Fagerland, Stein-Martin Tilrum; Berg, Sigrid; Hill, Deborah Katherine; Snipstad, Sofie; Sulheim, Einar; Hyldbakk, Astrid; Kim, Jana; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)Ultrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two ...