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dc.contributor.authorFagerland, Stein-Martin Tilrum
dc.contributor.authorBerg, Sigrid
dc.contributor.authorHill, Deborah Katherine
dc.contributor.authorSnipstad, Sofie
dc.contributor.authorSulheim, Einar
dc.contributor.authorHyldbakk, Astrid
dc.contributor.authorKim, Jana
dc.contributor.authorDavies, Catharina de Lange
dc.date.accessioned2021-01-08T13:09:11Z
dc.date.available2021-01-08T13:09:11Z
dc.date.created2020-09-07T15:55:11Z
dc.date.issued2020
dc.identifier.issn0301-5629
dc.identifier.urihttps://hdl.handle.net/11250/2722213
dc.description.abstractUltrasound (US) in combination with microbubbles (MB) has had promising results in improving delivery of chemotherapeutic agents. However, most studies are done in immunodeficient mice with xenografted tumors. We used two phenotypes of the spontaneous transgenic adenocarcinoma of the mouse prostate (TRAMP) model to evaluate if US + MB could enhance the therapeutic efficacy of cabazitaxel (Cab). Cab was either injected intravenously as free drug or encapsulated into nanoparticles. In both cases, Cab transiently reduced tumor and prostate volume in the TRAMP model. No additional therapeutic efficacy was observed combining Cab with US + MB, except for one tumor. Additionally, histology grading and immunostaining of Ki67 did not reveal differences between treatment groups. Mass spectrometry revealed that nanoparticle encapsulation of Cab increased the circulation time and enhanced the accumulation in liver and spleen compared with free Cab. The therapeutic results in this spontaneous, clinically relevant tumor model differ from the improved therapeutic response observed in xenografts combining US + MB and chemotherapy.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectProstate canceren_US
dc.subjectTRAMP modelen_US
dc.subjectTransgenic adenocarcinoma of the mouse prostate modelen_US
dc.subjectDrug deliveryen_US
dc.subjectMicrobubblesen_US
dc.subjectUltrasounden_US
dc.subjectCabazitaxelen_US
dc.subjectNanoparticleen_US
dc.titleUltrasound-Mediated Delivery of Chemotherapy into the Transgenic Adenocarcinoma of the Mouse Prostate Modelen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright © 2020 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.This is an open access article under the CC BY license.en_US
dc.source.pagenumber3032-3045en_US
dc.source.volume46en_US
dc.source.journalUltrasound in Medicine and Biologyen_US
dc.source.issue11en_US
dc.identifier.doi10.1016/j.ultrasmedbio.2020.07.004
dc.identifier.cristin1827881
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal