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dc.contributor.authorMørch, Ýrr Asbjørg
dc.contributor.authorHansen, Rune
dc.contributor.authorBerg, Sigrid
dc.contributor.authorÅslund, Andreas
dc.contributor.authorGlomm, Wilhelm
dc.contributor.authorEggen, Siv
dc.contributor.authorSchmid, Ruth
dc.contributor.authorJohnsen, Heidi
dc.contributor.authorKubowicz, Stephan
dc.contributor.authorSnipstad, Sofie
dc.contributor.authorSulheim, Einar
dc.contributor.authorHak, Sjoerd
dc.contributor.authorSingh, Gurvinder
dc.contributor.authorMcDonagh, Birgitte Hjelmeland
dc.contributor.authorBlom, Hans
dc.contributor.authorDavies, Ruth Catharina de Lange
dc.contributor.authorStenstad, Per Martin
dc.date.accessioned2019-08-12T08:04:21Z
dc.date.available2019-08-12T08:04:21Z
dc.date.created2015-11-19T08:47:18Z
dc.date.issued2015
dc.identifier.citationContrast Media & Molecular Imaging. 2015, 10 (5), 356-366.nb_NO
dc.identifier.issn1555-4309
dc.identifier.urihttp://hdl.handle.net/11250/2607826
dc.description.abstractMicrobubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology platform incorporating multiple functionalities, including imaging and therapy in a single system consisting of MBs stabilized by polyethylene glycol (PEG)-coated polymeric nanoparticles (NPs). The NPs, containing lipophilic drugs and/or contrast agents, are composed of the widely used poly(butyl cyanoacrylate) (PBCA) polymer and prepared in a single step. MBs stabilized by these NPs are subsequently prepared by self-assembly of NPs at the MB air–liquid interface. Here we show that these MBs can act as contrast agents for conventional ultrasound imaging. Successful encapsulation of iron oxide NPs inside the PBCA NPs is demonstrated, potentially enabling the NP–MBs to be used as magnetic resonance imaging (MRI) and/or molecular ultrasound imaging contrast agents. By precise tuning of the applied ultrasound pulse, the MBs burst and the NPs constituting the shell are released. This could result in increased local deposit of NPs into target tissue, providing improved therapy and imaging contrast compared with freely distributed NPs. Copyright © 2015 John Wiley & Sons, Ltd.nb_NO
dc.language.isoengnb_NO
dc.publisherJohn Wiley & Sons Ltdnb_NO
dc.rightsNavngivelse-Ikkekommersiell 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/deed.no*
dc.titleNanoparticle-stabilized microbubbles for multimodal imaging and drug deliverynb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionpublishedVersionnb_NO
dc.rights.holderCopyright © 2015 John Wiley & Sons, Ltdnb_NO
dc.source.pagenumber356-366nb_NO
dc.source.volume10nb_NO
dc.source.journalContrast Media & Molecular Imagingnb_NO
dc.source.issue5nb_NO
dc.identifier.doi10.1002/cmmi.1639
dc.identifier.cristin1290664
dc.relation.projectSamarbeidsorganet mellom Helse Midt-Norge og NTNU:nb_NO
dc.relation.projectNorges forskningsråd: 220005nb_NO
cristin.unitcode7401,80,1,4
cristin.unitcode7401,60,0,0
cristin.unitcode7401,80,6,4
cristin.unitcode7401,80,6,3
cristin.unitnamePolymerpartikler og overflatekjemi
cristin.unitnameSINTEF Teknologi og samfunn
cristin.unitnamePolymerer og komposittmaterialer
cristin.unitnamePolymerkjemi
cristin.ispublishedtrue
cristin.fulltextpreprint
cristin.qualitycode1


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