• A comparative biodistribution study of polymeric and lipid-based nanoparticles 

      Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)
      Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ...
    • A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS 

      Zabeo, Alex; Rosada, Fabio; Pizzol, Lisa; Caputo, Fanny; Borgos, Sven Even F.; Parot, Jérémie; Geertsma, Robert; Pouw, Joost Jacob; Vandebriel, Rob J.; Moreno, Oihane Ibarrola; Hristozov, Danail (Peer reviewed; Journal article, 2022)
      The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic ...
    • Interlaboratory evaluation of a digital holographic microscopy–based assay for label-free in vitro cytotoxicity testing of polymeric nanocarriers 

      Marzi, Anne; Eder, Kai Moritz; Barroso, Álvaro; Wågbø, Ane Marit; Mørch, Ýrr Asbjørg; Hatletveit, Anne Rein; Visnes, Torkild; Schmid, Ruth Baumberger; Klinkenberg, Geir; Kemper, Björn; Schnekenburger, Jürgen (Peer reviewed; Journal article, 2022)
      State-of-the-art in vitro test systems for nanomaterial toxicity assessment are based on dyes and several staining steps which can be affected by nanomaterial interference. Digital holographic microscopy (DHM), an ...
    • A multistep in vitro hemocompatibility testing protocol recapitulating the foreign body reaction to nanocarriers 

      Perugini, Valeria; Schmid, Ruth; Mørch, Ýrr Asbjørg; Texier, Isabelle; Brodde, Martin; Santin, Matteo (Peer reviewed; Journal article, 2022)
      The development of drug nanocarriers based on polymeric, lipid and ceramic biomaterials has been paving the way to precision medicine, where the delivery of poorly soluble active compounds and personalized doses are made ...
    • Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances 

      Minnema, Jordi; Borgos, Sven Even F.; Liptrott, Neill; Vandebriel, Rob J.; Delmaar, Christiaan (Peer reviewed; Journal article, 2022)
      The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and parametrize a physiologically ...
    • The solid progress of nanomedicine 

      Martins, Joao Pedro; Das Neves, José; de la Fuente, Maria; Celia, Christian; Florindo, Helena; Gunday-Tureli, Nazende; Popat, Amirali; Santos, Jose Luis; Sousa, Flavia; Schmid, Ruth; Wolfram, Joy; Sarmento, Bruno; Santos, Helder A. (Peer reviewed; Journal article, 2020)
      This commentary article conveys the views of the board of the Nanomedicine and Nanoscale Delivery Focus Group of the Controlled Release Society regarding the decision of the United States National Cancer Institute (NCI) ...
    • Standardization of an in vitro assay matrix to assess cytotoxicity of organic nanocarriers: a pilot interlaboratory comparison 

      Eder, Kai Moritz; Marzi, Anne; Wågbø, Ane Marit; Vermeulen, Jolanda P.; de la Fonteyne-Blankestijn, Liset J. J.; Rösslein, Matthias; Ossig, Rainer; Klinkenberg, Geir; Vandebriel, Rob J.; Schnekenburger, Jürgen (Peer reviewed; Journal article, 2022)
      Nanotechnologies such as nanoparticles are established components of new medical devices and pharmaceuticals. The use and distribution of these materials increases the requirement for standardized evaluation of possible ...
    • Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF-SIMS analysis 

      Vennemann, Antje; Breitenstein, Daniel; Tallarek, Elke; Mørch, Ýrr Asbjørg; Schmid, Ruth Baumberger; Wiemann, Martin (Peer reviewed; Journal article, 2022)
      The detection of biomedical organic nanocarriers in cells and tissues is still an experimental challenge. Here we developed an imaging strategy for the label-free detection of poly (ethylbutyl cyanoacrylate) (PEBCA) ...