• Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft 

      Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Peer reviewed; Journal article, 2021)
      We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl ...
    • Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery 

      Mørch, Ýrr Asbjørg; Hansen, Rune; Berg, Sigrid; Åslund, Andreas; Glomm, Wilhelm; Eggen, Siv; Schmid, Ruth; Johnsen, Heidi; Kubowicz, Stephan; Snipstad, Sofie; Sulheim, Einar; Hak, Sjoerd; Singh, Gurvinder; McDonagh, Birgitte Hjelmeland; Blom, Hans; Davies, Ruth Catharina de Lange; Stenstad, Per Martin (Journal article; Peer reviewed, 2015)
      Microbubbles (MBs) are routinely used as contrast agents for ultrasound imaging. The use of ultrasound in combination with MBs has also attracted attention as a method to enhance drug delivery. We have developed a technology ...
    • Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function 

      Lelu, Sylvie; Afadzi, Mercy; Berg, Sigrid; Åslund, Andreas; Torp, Sverre Helge; Sattler, Wolfgang; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)
      Focused ultrasound (FUS) in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans, thereby providing a time window for increased drug delivery into brain tissue. ...
    • Sonopermeation Enhances Uptake and Therapeutic Effect of Free and Encapsulated Cabazitaxel 

      Snipstad, Sofie; Mørch, Ýrr; Sulheim, Einar; Åslund, Andreas; Pedersen, André; Hansen, Rune; Davies, Catharina de Lange; Berg, Sigrid (Peer reviewed; Journal article, 2021)
      Delivery of drugs and nanomedicines to tumors is often heterogeneous and insufficient and, thus, of limited efficacy. Microbubbles in combination with ultrasound have been found to improve delivery to tumors, enhancing ...
    • The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy 

      Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)
      Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ...
    • Therapeutic Effect of Cabazitaxel and Blood-Brain Barrier opening in a Patient-Derived Glioblastoma Model 

      Sulheim, Einar; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Borgos, Sven Even F.; Miletic, Hrvoje; Bjerkvig, Rolf; Davies, Catharina de Lange; Åslund, Andreas (Peer reviewed, 2019)
      Treatment of glioblastoma and other diseases in the brain is especially challenging due to the blood-brain barrier, which effectively protects the brain parenchyma. In this study we show for the first time that cabazitaxel, ...