• Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models 

      Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Peer reviewed; Journal article, 2018)
      Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...
    • Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts 

      Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2017)
      Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ...
    • Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes 

      Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Sofie; van Wamel, Annemieke; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andersen, Thomas L.; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)
      To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ...