• Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects 

      Baquero, Juan Miguel; Benitez-Buelga, Carlos; Rajagopal, Varshni; Zhenjun, Zhao; Torres-Ruiz, Raúl; Müller, Sarah; Hanna, Bishoy Magdi Fekry; Loseva, Olga; Wallner, Olov; Michel, Maurice; Rodriguez-Perales, Sandra; Gad, Helge; Visnes, Torkild; Helleday, Thomas; Benitez, Javier; Osario, Ana (Peer reviewed; Journal article, 2021)
      The most common oxidative DNA lesion is 8-oxoguanine which is mainly recognized and excised by the 8-oxoG DNA glycosylase 1 (OGG1), initiating the base excision repair (BER) pathway. Telomeres are particularly sensitive ...