• Biophysical Characterization of Viral and Lipid-Based Vectors for Vaccines and Therapeutics with Light Scattering and Calorimetric Techniques 

      Markova, Natalia; Cairns, Stefan; Jankevics-Jones, Hanna; Kaszuba, Michael; Caputo, Fanny; Parot, Jérémie (Peer reviewed; Journal article, 2022)
      Novel vaccine platforms for delivery of nucleic acids based on viral and non-viral vectors, such as recombinant adeno associated viruses (rAAV) and lipid-based nanoparticles (LNPs), hold great promise. However, they pose ...
    • Cryo-XPS for Surface Characterization of Nanomedicines 

      Cant, David J H; Pei, Yiwen; Shchukarev, Andrey; Ramstedt, Madeleine; Marques, Sara S.; Segundo, Marcela A.; Parot, Jérémie; Molska, Alicja Anna; Borgos, Sven Even F.; Shard, Alexander G.; Minelli, Caterina (Peer reviewed; Journal article, 2023)
      Nanoparticles used for medical applications commonly possess coatings or surface functionalities intended to provide specific behavior in vivo, for example, the use of PEG to provide stealth properties. Direct, quantitative ...
    • A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS 

      Zabeo, Alex; Rosada, Fabio; Pizzol, Lisa; Caputo, Fanny; Borgos, Sven Even F.; Parot, Jérémie; Geertsma, Robert; Pouw, Joost Jacob; Vandebriel, Rob J.; Moreno, Oihane Ibarrola; Hristozov, Danail (Peer reviewed; Journal article, 2022)
      The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic ...
    • Detection, counting and characterization of nanoplastics in marine bioindicators: a proof of principle study. 

      Valsesia, Andrea; Parot, Jérémie; Ponti, Jessica; Mehn, Dora; Marino, Rita; Melillo, Daniela; Muramoto, Shin; Verkouteren, Mike; Hackley, Vincent A.; Colpo, Pascal (Peer reviewed; Journal article, 2021)
      Plastic particulates in the environment pose an increasing concern for regulatory bodies due to their potential risk to higher organisms (including humans) as they enter the food chain. Nanoplastics (defined here as smaller ...
    • Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods 

      Huber, Maximilian J.; Ivleva, Natalia P.; Booth, Andy; Beer, Irina; Bianchi, Ivana; Drexel, Roland; Geiss, Otmar; Mehn, Dora; Meier, Florian; Molska, Alicja Anna; Parot, Jérémie; Sørensen, Lisbet; Vella, Gabriele; Prina‑Mello, Adriele; Vogel, Robert; Caputo, Fanny (Peer reviewed; Journal article, 2023)
      A comprehensive physicochemical characterization of heterogeneous nanoplastic (NPL) samples remains an analytical challenge requiring a combination of orthogonal measurement techniques to improve the accuracy and robustness ...