Browsing SINTEF Industri by Author "Calzolai, Luigi"
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2020)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Bridging communities in the field of nanomedicine
Halamoda-Kenzaoui, Blanka; Baconnier, Simon; Bastogne, Thierry; Bazile, Didier; Boisseau, Patrick; Borchard, Gerrit; Borgos, Sven Even F.; Calzolai, Luigi; Cederbrant, Karin; Di Felice, Gabriella; Di Francesco, Tiziana; Dobrovolskaia, Marina A.; Gaspar, Rogério; Gracia, Belén; Hackley, Vincent A.; Leyens, Lada; Liptrott, Neill; Park, Margriet; Patri, Anil; Roebben, Gert; Roesslein, Matthias; Thürmer, René; Urbán, Patricia; Zuang, Valérie; Bremer-Hoffmann, Susanne (Journal article; Peer reviewed, 2019)An early dialogue between nanomedicine developers and regulatory authorities are of utmost importance to anticipate quality and safety requirements for these innovative health products. In order to stimulate interactions between ... -
In depth characterization of physicochemical critical quality attributes of a clinical drug-dendrimer conjugate
Sonzini, Silvia; Caputo, Fanny; Mehn, Dora; Calzolai, Luigi; Borgos, Sven Even F.; Hyldbakk, Astrid; Treacher, Kevin; Li, Weimin; Jackman, Mark; Mahmoudi, Najet; Lawrence, M. Jayne; Patterson, Claire; Owen, David; Ashford, Marianne B; Akhtar, Nadim (Peer reviewed; Journal article, 2023)A deep and detailed understanding of drug-dendrimer conjugates key properties is needed to define the critical quality attributes that affect drug product performance. The characterization must be executed both in the ... -
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?
Vogel, Robert; Savage, John; Muzard, Julien; Camera, Giacomo Della; Vella, Gabriele; Law, Alice; Marchioni, Marianne; Mehn, Dora; Geiss, Otmar; Peacock, Ben; Aubert, Dimitri; Calzolai, Luigi; Caputo, Fanny; Prina-Mello, Adriele (Peer reviewed; Journal article, 2021)The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation ... -
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
Caputo, Fanny; Vogel, R.; Savage, J.; Vella, G.; Law, A.; Della Camera, Camera; Hannon, G.; Peacock, B.; Mehn, Dora; Ponti, J.; Geiss, Otmar; Aubert, D.; Prina-Mello, Adriele; Calzolai, Luigi (Peer reviewed; Journal article, 2021)HYPOTHESIS:The implementation of the proposal from the European Chemical Agency (ECHA) to restrict the use of nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods to perform size and ... -
Orthogonal and complementary measurements of properties of drug products containing nanomaterials
Simon, Carl; Borgos, Sven Even F.; Calzolai, Luigi; Nelson, Bryant C.; Parot, Jérémie; Petersen, Elijah. J; Rösslein, Matthias; Xu, Xiaoming; Caputo, Fanny (Peer reviewed; Journal article, 2023)Quality control of pharmaceutical and biopharmaceutical products, and verification of their safety and efficacy, depends on reliable measurements of critical quality attributes (CQAs). The task becomes particularly challenging ... -
Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques
Parot, Jérémie; Mehn, Dora; Jankevics-Jones, Hanna; Markova, Natalia; Carboni, Michele; Olaisen, Camilla; Hoel, Andrea Draget; Sigfúsdóttir, Margrét S.; Meier, Florian; Drexel, Roland; Vella, Gabriella; Mcdonagh, Birgitte Hjelmeland; Hansen, Terkel; Bui, Huong; Klinkenberg, Geir; Visnes, Torkild; Gioria, Sabrina; Urban-Lopez, Patricia; Prina-Mello, Adriele; Borgos, Sven Even F.; Caputo, Fanny; Calzolai, Luigi (Peer reviewed; Journal article, 2024)The availability of analytical methods for the characterization of lipid nanoparticles (LNPs) for in-vivo intracellular delivery of nucleic acids is critical for the fast development of innovative RNA therapies. In this ...