Blar i SINTEF Open på forfatter "Caputo, Fanny"
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2020)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Caputo, Fanny; Mehn, Dora; Clogston, Jeffrey; Rösslein, Matthias; Prina-Mello, Adriele; Borgos, Sven Even F.; Gioria, Sabrina; Calzolai, Luigi (Peer reviewed; Journal article, 2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Biophysical Characterization of Viral and Lipid-Based Vectors for Vaccines and Therapeutics with Light Scattering and Calorimetric Techniques
Markova, Natalia; Cairns, Stefan; Jankevics-Jones, Hanna; Kaszuba, Michael; Caputo, Fanny; Parot, Jérémie (Peer reviewed; Journal article, 2022)Novel vaccine platforms for delivery of nucleic acids based on viral and non-viral vectors, such as recombinant adeno associated viruses (rAAV) and lipid-based nanoparticles (LNPs), hold great promise. However, they pose ... -
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Åslund, Andreas; Vandebriel, Rob J.; Caputo, Fanny; de Jong, Wim H.; Delmaar, Christiaan; Hyldbakk, Astrid; Rustique, Emilie; Schmid, Ruth Baumberger; Snipstad, Sofie; Texier, Isabelle; Vernstad, Kai; Borgos, Sven Even F. (Peer reviewed; Journal article, 2022)Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical ... -
A Decision Support System for preclinical assessment of nanomaterials in medical products: the REFINE DSS
Zabeo, Alex; Rosada, Fabio; Pizzol, Lisa; Caputo, Fanny; Borgos, Sven Even F.; Parot, Jérémie; Geertsma, Robert; Pouw, Joost Jacob; Vandebriel, Rob J.; Moreno, Oihane Ibarrola; Hristozov, Danail (Peer reviewed; Journal article, 2022)The application of nanomaterials in medicine has led to novel pharmaceuticals and medical devices that have demonstrated a strong potential for increasing the efficacy/performance and safety of therapeutic and diagnostic ... -
Delivering the power of nanomedicine to patients today
Germain, Matthieu; Caputo, Fanny; Metcalfe, Su; Tosi, Giovanni; Spring, Kathleen; Åslund, Andreas K.O.; Pottier, Agnes; Schiffelers, Raymond; Ceccaldi, Alexandre; Schmid, Ruth (Peer reviewed; Journal article, 2020)The situation of the COVID-19 pandemic reminds us that we permanently need high-value flexible solutions to urgent clinical needs including simplified diagnostic technologies suitable for use in the field and for delivering ... -
Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
Mildner, Robert; Hak, Sjoerd; Parot, Jeremie; Hyldbakk, Astrid; Borgos, Sven Even F.; some, dan; Johann, Cristoph; Caputo, Fanny (Peer reviewed; Journal article, 2021)Lipid-based nanoparticles for RNA delivery (LNP-RNA) are revolutionizing the nanomedicine field, with one approved gene therapy formulation and two approved vaccines against COVID-19, as well as multiple ongoing clinical ... -
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?
Vogel, Robert; Savage, John; Muzard, Julien; Camera, Giacomo Della; Vella, Gabriele; Law, Alice; Marchioni, Marianne; Mehn, Dora; Geiss, Otmar; Peacock, Ben; Aubert, Dimitri; Calzolai, Luigi; Caputo, Fanny; Prina-Mello, Adriele (Peer reviewed; Journal article, 2021)The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation ... -
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
Caputo, Fanny; Vogel, R.; Savage, J.; Vella, G.; Law, A.; Della Camera, Camera; Hannon, G.; Peacock, B.; Mehn, Dora; Ponti, J.; Geiss, Otmar; Aubert, D.; Prina-Mello, Adriele; Calzolai, Luigi (Peer reviewed; Journal article, 2021)HYPOTHESIS:The implementation of the proposal from the European Chemical Agency (ECHA) to restrict the use of nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods to perform size and ... -
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation
Halamoda-Kenzaoui, Blanka; Vandebriel, Rob; Howarth, Alice; Siccardi, Marco; David, Chris; Liptrott, Neill; Santin, Marco; Borgos, Sven Even F.; Bremer-Hoffmann, Susanne; Caputo, Fanny (Peer reviewed; Journal article, 2021)Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available ... -
Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation
Halamoda-Kenzaoui, Blanka; Vandebriel, Rob; Howarth, Alice; Siccardi, Marco; David, Chris; Liptrott, Neill; Santin, Marco; Borgos, Sven Even F.; Bremer-Hoffmann, Susanne; Caputo, Fanny (Peer reviewed; Journal article, 2021)Nanotechnology-based health products are providing innovative solutions in health technologies and the pharmaceutical field, responding to unmet clinical needs. However, suitable standardised methods need to be available ... -
Physicochemical characterization and quantification of nanoplastics: applicability, limitations and complementarity of batch and fractionation methods
Huber, Maximilian J.; Ivleva, Natalia P.; Booth, Andy; Beer, Irina; Bianchi, Ivana; Drexel, Roland; Geiss, Otmar; Mehn, Dora; Meier, Florian; Molska, Alicja Anna; Parot, Jérémie; Sørensen, Lisbet; Vella, Gabriele; Prina‑Mello, Adriele; Vogel, Robert; Caputo, Fanny (Peer reviewed; Journal article, 2023)A comprehensive physicochemical characterization of heterogeneous nanoplastic (NPL) samples remains an analytical challenge requiring a combination of orthogonal measurement techniques to improve the accuracy and robustness ... -
Quality assessment of LNP-RNA therapeutics with orthogonal analytical techniques
Parot, Jérémie; Mehn, Dora; Jankevics-Jones, Hanna; Markova, Natalia; Carboni, Michele; Olaisen, Camilla; Hoel, Andrea Draget; Sigfúsdóttir, Margrét S.; Meier, Florian; Drexel, Roland; Vella, Gabriella; Mcdonagh, Birgitte Hjelmeland; Hansen, Terkel; Bui, Huong; Klinkenberg, Geir; Visnes, Torkild; Gioria, Sabrina; Urban-Lopez, Patricia; Prina-Mello, Adriele; Borgos, Sven Even F.; Caputo, Fanny; Calzolai, Luigi (Peer reviewed; Journal article, 2024)The availability of analytical methods for the characterization of lipid nanoparticles (LNPs) for in-vivo intracellular delivery of nucleic acids is critical for the fast development of innovative RNA therapies. In this ...